Nambarka kaska: 21187-98-4 Formula Molecular
Meesha dhalaalaysa | 163-169 °C |
Cufnaanta | 1.2205 (qiyaas adag) |
heerkulka kaydinta | Jawi aan firfircoonayn, heerkulka qolka 2-8°C |
milmayn | methylene chloride: milmay |
dhaqdhaqaaqa indhaha | N/A |
Muuqashada | Off-White Solid |
daahirnimo | ≥98% |
waa wakiilka antihyperglycemic afka ee loo isticmaalo daawaynta sonkorowga mellitus nooca II.Waxay ka tirsan tahay fasalka sulfonylurea ee qarsoodiga insulin, kaas oo kiciya unugyada β ee xameetida si ay u sii daayaan insulinta.waxay ku xidhan tahay β-cell sulfonyl urea reseptor (SUR1), oo sii xannibaysa kanaalada potassium ee xasaasiga ah ee ATP.Sidaa darteed, dheecaanka potassium ayaa si aad ah hoos ugu dhacaya, taas oo keenta depolarization unugyada β.Kadibna kanaalada calcium-ku-tiirsan ee ku-tiirsanaanta unugyada β way furan yihiin, taasoo keentay firfircoonida calmodulin, taas oo iyaduna keenta exocytosis ee insulinta oo ay ku jiraan granules sirta ah.Daraasadihii ugu dambeeyay ayaa sidoo kale muujiyay in ay si wax ku ool ah u wanaajin karto heerka anti-oxidant iyo nitric oxide-mediated vasodilation ee Nooca 2 ee sonkorowga iyo ka ilaalinta unugyada beta-pancreatic ee waxyeelada hydrogen peroxide.
waa wakiilka hypoglycemic afka ee loo isticmaalo in lagu daaweeyo sonkorowga mellitus ee aan insulin-ku-tiirsanayn. cuntada galay tamar.waxay yaraynaysaa heerarka gulukooska dhiigga iyada oo kicinaysa dheecaanka insulinta ee unugyada β-unugyada jasiiradaha Langerhans.