l Nambarka kaska: 171596-29-5 Formula Molecular: C₂₂H₁₉N₃O₄
| Meesha dhalaalaysa | >193°C |
| Cufnaanta | DMF: 25 mg/ml DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml DMSO: 20 mg/ml |
| heerkulka kaydinta | -20°C |
| milmayn | DMF: 25 mg/ml DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml DMSO: 20 mg/ml |
| dhaqdhaqaaqa indhaha | [α]/D +68 ilaa +78°, c = 1 ee chloroform-d |
| Muuqashada | Cadaan ilaa Cadaan Adag |
| daahirnimo | ≥98% |
(magaca suuqa ama) waa nooc ka mid ah PDE5 inhibitor loo isticmaalo daawaynta cillad la'aanta kacsiga, hypertrophy qanjirka 'prostatic' ee aan fiicnayn iyo dhiig-karka halbowlayaasha sambabada.Saamaynta ay leedahay waa nasinta murqaha xididdada dhiigga iyo kordhinta qulqulka dhiigga ee cavernosum.Habka ficilku waa iyada oo la joojinayo dhaqdhaqaaqa cGMP nooca fosfodiesterase ee gaarka ah 5 (PDE5).PDE5 waxay hoos u dhigtaa cGMP ee godka corpus ee ku yaal agagaarka guska.Sidaa darteed, tadalafi waxay keenaysaa xoojinta korodhka cGMP taas oo sii kordhinaysa nasashada muruqa oo siman iyo socodka dhiigga oo kordha ee cavernosum corpus.Daraasadaha kiliinikada qaarkood ayaa sidoo kale tilmaamay in ay hagaajin karaan shaqada endothelia ee ragga leh khatarta wadnaha iyo xididada oo sii kordhaya waxayna hoos u dhigtaa calaamadaha kaadi-mareenka ee ka hooseeya qanjirka 'prostatic hyperplasia'.
xanuun joojiyaha, xannibaadaha qaadashada, mu-opiod agonist receptor.Fosfodiesterase 5 inhibitor ah.waxaa loo isticmaalaa daawaynta cillad la'aanta kacsiga.
wuu ka duwan yahay qaab dhismeedka labada sildenafil iyo vardenafil.Si degdeg ah ayaa loo nuugo oo kor ugu qaadaa fiirsashada (378 μg/L ka dib qiyaasta 20-mg) ka dib 2 saacadood, oo muujinaysa nolol badhkeed oo dheer oo ah saacadaha 17.5.Waxa kale oo lagu dheefshiido beerka (CYP3A4).Waxaa xusid mudan, farmashiyeheeda caafimaad ahaan kuma laha aalkolo ama cunto qaadashada ama arrimo ay ka mid yihiin sonkorowga ama beerka ama kelyaha oo daciifa.
