Nambarka kaska: 330784-47-9 Formula Molecular: C23H26ClN7O3

Alaabta

Nambarka kaska: 330784-47-9 Formula Molecular: C23H26ClN7O3

Sharaxaad Gaaban:

Lambarka Cas: 330784-47-9

Magaca Kiimikada:

Qaacidada Molecular:C23H26ClN7O3

La mid ah: (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4- (3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine

4-[(3-Chloro-4-methoxybenzyl) amino]-2-[2- (hydroxymethyl) -1-pyrrolidinyl]-N- (2-pyrimidinylmethyl) -5-pyrimidinecarboxamide


Faahfaahinta Alaabta

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Tilmaamaha Alaabta

Meesha dhalaalaysa 150-152°C
Cufnaanta 1.372
heerkulka kaydinta Waxaa lagu xidhay qalalan, ku kaydi qaboojiyaha, ka hooseeya -20 ° C
milmayn DMSO (wax yar), Methanol (wax yar, kuleyl)
dhaqdhaqaaqa indhaha N/A
Muuqashada Cadaan ilaa cad-cad
daahirnimo ≥98%

farmashiyaha

(Zepeed) waxaa u ansixisay Wasaaradda Caafimaadka Kuuriya daawaynta cillad la'aanta kacsiga (ED) ee Agoosto 2011. waa nooca 5 phosphodiesterase (PDE5) inhibitor ah oo aad loo xushay.waxaa lagu soo waramayaa inuu yahay ka-hortagga PDE5 ee ugu xulashada badan suuqa.Bilawga Tmax iyo nolosha badhku waxay sidoo kale ku kala duwan yihiin ka hortagga PDE5 ee la suuqgeeyay.Sildenafil wuxuu leeyahay Tmax1 saac iyo nolol badhkeed oo ah 3-5 saacadood.Vardenafil waxay la mid tahay Tmaxoo ah 0.6 saacadood iyo nolol badhkeed oo ah 4-6 saacadood.Tadalafil waxay leedahay nolosha nuska ah ee ugu dheer ee ka mid ah daroogooyinka la iibiyo oo leh nuska nolosha 17 h.waxay leedahay bilaw degdeg ah oo ficil ah oo gaadhay Tmaxgudaha 0.6 saac oo leh nolol nus ah 1.2 saac.Isku-dubarid (TA-1790) ayaa lagu qeexay suugaanta patent-ka.Dariiqa ugu weyn ee baabi'inta waa iyada oo loo marayo xashiishka iyo saxarada.ayaa sidoo kale la ogaaday in dib loo soo celiyay iyada oo loo marayo dib-u-wareejinta enterohepatic.

isticmaal

Fosfodiesterase (PDE5) inhibitor, oo loo isticmaalo daawaynta cillad la'aanta kacsiga.

isticmaalka iyo qiyaasta

waa PDE5 inhibitor aad u doorta oo leh IC50 ee 1 nM.

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