Cetilistat Kaska nambarka: 282526-98-1 Qaaciddada Molecular: C25H39NO3
| Meesha dhalaalaysa | 72.0 ilaa 76.0C |
| Cufnaanta | 1.02 |
| heerkulka kaydinta | Waxaa lagu daboolay qallalan, 2-8 ° C |
| milmayn | Chloroform (wax yar), Ethyl Acetate (wax yar) |
| dhaqdhaqaaqa indhaha | N/A |
| Muuqashada | Cryst Off-cad |
| daahirnimo | ≥98% |
Cetilistat (oo sidoo kale loo yaqaan ATL-962) ayaa la ansixiyay Sebtembar 2013 Wasaaradda Caafimaadka, Shaqada iyo Daryeelka ee Japan si loogu daweeyo buurnaanta, oo ku xaddidan bukaanada qaba nooca 2 ee sonkorowga mellitus (T2DM) iyo dyslipidemia, iyo cufnaanta jirka. index (BMI) 25 kg/m2inkastoo daaweynta cuntada iyo/ama daaweynta jimicsiga.Sida orlistat, cetilistat waxay u shaqeysaa iyada oo la xakameynayo lipases pancreatic ee mindhicirka si loo joojiyo nuugista baruurta oo ay hoos u dhigto qaadashada kalooriga ee cuntada.Barnaamijka kimistariga daawada laguma sifeyn suugaanta sayniska, laakiin patent-ka qeexaya cetilistat wuxuu sidoo kale qeexayaa isku-dhafka analogs oo leh noocyo kala duwan oo aryl ah iyo dabo lipophilic ah.Isku-dubaridka cetilistat waxay ku lug leedahay uumi hexadecylcarbonochloridate oo leh 2-amino-5-methylbenzoic acid;Analoogyada kale ayaa la sameeyay iyadoo lagu kala duwanaanayo carbonochloridet iyo 2-aminobenzoic acid qaybaha.Cetilistat waa horjooge awood leh oo dadka iyo lipase ganaca leh ee IC50aadee 15 iyo 136 nM, siday u kala horreeyaan, oo leh xannibaad yar oo ah trypsin ama chymotrypsin.
A novel lipase inhibitor pancreatic lipase inhibitor oo loogu talagalay daawaynta buurnaanta ee bukaanka sokorowga iyo kuwa aan qabin labadaba.
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