Nambarka kaska: 144701-48-4 Formula Molecular: C33H30N4O2

Sharaxaad Gaaban:

Lambarka Cas: 144701-48-4
Magaca Kiimikada:
Qaacidada molecular:C33H30N4O2

La mid ah:MICARDIS;TU-199;Telmisaran;TIMISHATAN;2-(4-{[4-Methyl-6-(1-Methyl-1H-1,3-benzodiazol-2-yl))-2-propyl-1H-1 ,3-benzodiazol-1-yl]Methyl}phenyl) benzoic acid;4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl) methyl ][1,1′-biphenyl]-2-carboxylic acid, BIBR 277;PRITOR;BIBR 277;misartan;BIBR 277SE

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Faahfaahinta Alaabta

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Tilmaamaha Alaabta

Meesha dhalaalaysa	261-263°C
Cufnaanta	1.16 (Qiyaas adag)
heerkulka kaydinta	Jawi aan firfircoonayn, heerkulka qolka 2-8°C
milmayn	DMSO:>5 mg/ml at 60°C
dhaqdhaqaaqa indhaha	N/A
Muuqashada	Off-White Solid
daahirnimo	≥98%

Sharaxaada

ayaa laga bilaabay Maraykanka si loogu daweeyo dhiig-karka.Waxaa lagu diyaarin karaa siddeed tallaabo oo ka bilaabma methyl 4-amino-3-methyl benzoate;Wareegga koowaad iyo labaad ee giraanta benzimidazole waxay ku dhacdaa tallaabooyinka 4 iyo 6 siday u kala horreeyaan.waxay xannibaysaa ficilka angiotensin II (Ang II), molecule-ka saamaynta aasaasiga ah ee nidaamka renin-angiotensin-aldosterone (RAAS).Waa fasalka lixaad ee 《sartans》 in la suuq galiyo ka dib xarunta sunta rasaasta ee Losartan.Saameynteeda dheer (nolosha nuska 24) waxay noqon kartaa faraqa ugu weyn ee antagonistayaasha kale ee angiotensin II.Si ka duwan dhowr wakiil oo kale oo ka tirsan qaybtan, shaqadeedu kuma xidhna marka loo beddelo dheef-shiid kiimikaad firfircoon, 1-O-acylglucuronide oo ah dheef-shiid kiimikaadka ugu muhiimsan ee laga helo bini'aadamka. angiotensin II iyada oo ay ka maqan tahay isku xirnaanta AT2-hoosaadka ama daaweeyayaasha kale ee ku lug leh nidaaminta wadnaha iyo xididdada.Dhowr daraasadood oo kiliinig ah, hal mar qiyaasta maalinlaha ah, waxay soo saartay wax ku ool ah oo joogto ah hoos u dhigista cadaadiska dhiigga oo leh saameyn hoose oo saameynaya (gaar ahaan daawaynta la xiriirta qufaca oo la xidhiidha ACE inhibitors ee bukaanka waayeelka ah).